Prof. Kai Hilpert, St George's, University of Londonprivat

Visiting Scientist from St George's, University of London at the IAI

  • Source: IAI
  • Date: 2022-04-21, updated 2022-04-27
  • Kai Hilpert is a guest scientist visiting the ML4TIME group. He is an associate Professor from St George's, University of London. For many years he has been developing new antimicrobial compounds (peptides) against multi-drug resistant pathogenic bacteria. In a new study from 2022, it was reported that in 2019 about 1.27 million people died as a consequence of infections caused by resistant bacteria and 4.95 million deaths were associated with antimicrobial resistance. These numbers show the dimensions of the burden caused by infectious micro­organisms where no treatment is available. In addition, other medical procedures like operations, transplantations, and chemo­therapy would be not possible or at very high risk in case no antibiotics are effective anymore. Antimicrobial resistance is an ongoing problem that intensified with a loss of investment and interest in most larger pharma companies in the last decades. Consequently, a gap in antimicrobial drug development appeared, for nearly 40 years no new structural class was developed. Kai Hilpert and Ralf Mikut will work on the analysis of screening data for antimicrobial activity and toxicity to identify and understand novel antimicrobials synthesized in the group of Kai Hilpert. His stay will last until early June 2022.

Publications


2021
Rational Designed Hybrid Peptides Show up to a 6-Fold Increase in Antimicrobial Activity and Demonstrate Different Ultrastructural Changes as the Parental Peptides Measured by BioSAXS
Hilpert, K.; Gani, J.; Rumancev, C.; Simpson, N.; Lopez-Perez, P. M.; Garamus, V. M.; Gundlach, A. R. von; Markov, P.; Scocchi, M.; Mikut, R.; Rosenhahn, A.
2021. Frontiers in pharmacology, 12, Article no: 769739. doi:10.3389/fphar.2021.769739
2020
The effect of lipidation and glycosylation on short cationic antimicrobial peptides
Grimsey, E.; Collis, D. W. P.; Mikut, R.; Hilpert, K.
2020. Biochimica et biophysica acta / Biomembranes, 1862 (8), Art.Nr.: 183195. doi:10.1016/j.bbamem.2020.183195
2019
Synergy Pattern of Short Cationic Antimicrobial Peptides Against Multidrug-Resistant Pseudomonas aeruginosa
Ruden, S.; Rieder, A.; Chis Ster, I.; Schwartz, T.; Mikut, R.; Hilpert, K.
2019. Frontiers in microbiology, 10, Art. Nr.: 2740. doi:10.3389/fmicb.2019.02740
BioSAXS Measurements Reveal That Two Antimicrobial Peptides Induce Similar Molecular Changes in Gram-Negative and Gram-Positive Bacteria
Gundlach, A. von; Ashby, M. P.; Gani, J.; Lopez-Perez, P. M.; Cookson, A. R.; Ann Huws, S.; Rumancev, C.; Garamus, V. M.; Mikut, R.; Rosenhahn, A.; Hilpert, K.
2019. Frontiers in pharmacology, 10, Art. Nr.: 1127. doi:10.3389/fphar.2019.01127
Ruminal antimicrobial peptides as promising molecules to treat pathogenic bacteria, including resistant strains
Oyama, L. B.; Olleik, H.; Nery Teixeira, A. C.; Guidini, M. M.; Maresca, M.; Bazzolli, D.; Cookson, A. C.; Fuentes, N. F.; Vallin, H.; Pickup, J.; Mikut, R.; Hilpert, K.; Richards, J.; Wootton, M.; Edwards, J. E.; Perrier, J.; Hess, M.; Mantovani, H. C.; Creevey, C. J.; Huws, S. A.
2019. Gordon Research Conference - Antimicrobial Peptides: Mechanisms and Application: Realizing the Potential of Antimicrobial Host Defense Peptides for Human and Veterinary Medicine (GRC 2019), Lucca, Italy, February 24–March 1, 2019
In silico identification of novel peptides with antibacterial activity against multidrug resistant Staphylococcus aureus
Oyama, L. B.; Olleik, H.; Nery Teixeira, A. C.; Guidini, M. M.; Pickup, J. A.; Cookson, A. R.; Vallin, H.; Wilkinson, T.; Bazzolli, D.; Richards, J.; Wootton, M.; Mikut, R.; Hilpert, K.; Maresca, M.; Perrier, J.; Hess, M.; Mantovani, H. C.; Fernandez-Fuentes, N.; Creevey, C. J.; Huws, S. A.
2019. bioRxiv beta, 42 S. doi:10.1101/577221
2017
The rumen microbiome : an underexplored resource for novel antimicrobial discovery
Oyama, L. B.; Girdwood, S. E.; Cookson, A. R.; Fernandez-Fuentes, N.; Privé, F.; Vallin, H. E.; Wilkinson, T. J.; Golyshin, P. N.; Golyshina, O. V.; Mikut, R.; Hilpert, K.; Richards, J.; Wootton, M.; Edwards, J. E.; Maresca, M.; Perrier, J.; Lundy, F. T.; Luo, Y.; Zhou, M.; Hess, M.; Mantovani, H. C.; Creevey, C. J.; Huws, S. A.
2017. npj Biofilms and Microbiomes, 3 (1), Art.Nr. 33. doi:10.1038/s41522-017-0042-1
Screening and Optimizing Antimicrobial Peptides by Using SPOT-Synthesis
López-Pérez, P. M.; Grimsey, E.; Bourne, L.; Mikut, R.; Hilpert, K.
2017. Frontiers in Chemistry, 5, Article 25. doi:10.3389/fchem.2017.00025
Use of Peptide Libraries for Identification and Optimization of Novel Antimicrobial Peptides
Ashby, M.; Petkova, A.; Gani, J.; Mikut, R.; Hilpert, K.
2017. Current topics in medicinal chemistry, 17 (5), 537–553. doi:10.2174/1568026616666160713125555
2016
Rumen derived antimicrobials as a solution to evolving and persistent clinical infections
Oyama, L. B.; Girdwood, S. E.; Cookson, A.; Fernandez-Fuentes, N.; Edwards, J. E.; Golyshin, P.; Golyshina, O.; Prive, F.; Mikut, R.; Hilpert, K.; Creevey, C. J.; Huws, S. A.
2016. INRA-ROWETT 2016, Gut Microbiology Symposium, Clemont, F, June 20-23, 2016
Anti-MRSA activity of novel antimicrobial peptides identified from cow metagenome
Oyama, L. B.; Girdwood, S. E.; Cookson, A.; Fernandez-Fuentes, N.; Prive, F.; Edwards, J. E.; Golyshin, P.; Golyshina, O.; Mikut, R.; Hilpert, K.; Hess, M.; Creeveyand, C.; Huws, S. A.
2016. New Antibacterial Discovery and Development : Gordon-Kenan Research Seminar, Lucca, I, March 12-13, 2016
Small angle X-ray scattering as a high-throughput method to classify antimicrobial modes of action
Gundlach, A. R. von; Garamus, V. M.; Gorniak, T.; Davies, H. A.; Reischl, M.; Mikut, R.; Hilpert, K.; Rosenhahn, A.
2016. Biochimica et Biophysica Acta - Biomembranes, 1858 (5), 918–925. doi:10.1016/j.bbamem.2015.12.022
Improving short antimicrobial peptides despite elusive rules for activity
Mikut, R.; Ruden, S.; Reischl, M.; Breitling, F.; Volkmer, R.; Hilpert, K.
2016. Biochimica et Biophysica Acta - Biomembranes, 1858 (5), 1024–1033. doi:10.1016/j.bbamem.2015.12.013
Optimization of oncocin for antibacterial activity using a SPOT synthesis approach: Extending the pathogen spectrum to Staphylococcus aureus
Knappe, D.; Ruden, S.; Langanke, S.; Tikkoo, T.; Ritzer, J.; Mikut, R.; Martin, L. L.; Hoffmann, R.; Hilpert, K.
2016. Amino Acids, 48 (1), 269–280. doi:10.1007/s00726-015-2082-2
2015
Antimicrobial activity of two novel antimicrobial peptides identified in cow metagenome
Oyama, L. B.; Girdwood, S. E.; Cookson, A.; Fernandez-Fuentes, N.; Edwards, J. E.; Golyshin, P.; Golyshina, O.; Prive, F.; Mikut, R.; Hilpert, K.; Creevey, C.; Huws, S. A.
2015. 5th International Meeting on Antimicrobial Peptides (IMAP 2015), London, GB, September 7-8, 2015
Interaction of blood components with cathelicidins and their modified versions
Yu, K.; Lai, B. F. L.; Gani, J.; Mikut, R.; Hilpert, K.; Kizhakkedathu, J. N.
2015. Biomaterials, 69, 201–211. doi:10.1016/j.biomaterials.2015.08.003
2014
Optimizing the therapeutic potential of short antimicrobial peptides
Ruden, S.; Gani, J.; Ashby, M.; Mikut, R.; Hilpert, K.
2014. 4th International Meeting on Antimicrobial Peptides (IMAP 2014), Graz, A, September 29-30, 2014
2013
Targeting mycobacterium tuberculosis and other microbial pathogens using improved synthetic antibacterial peptides
Ramon-Garcia, S.; Mikut, R.; Ng, C.; Ruden, S.; Volkmer, R.; Reischl, M.; Hilpert, K.; Thompson, C. J.
2013. Antimicrobial Agents and Chemotherapy, 57, 2295–2303. doi:10.1128/AAC.00175-13
2010
Discovery of novel short cationic antimicrobial peptides with therapeutic potential by combining medium throughput screening and different QSAR approaches
Hilpert, K.; Ruden, S.; Hancock, R.; Mikut, R.
2010. MipTec Drug Discovery Conf.and Exhibition, Basel, CH, September 20-24, 2010 Journal of Peptide Science, 16(2010) Suppl.1, (Abstract)
Short cationic host defense peptides: determination of sequence requirements for killing pseudomonas aeruginosa
Mikut, R.; Hilpert, K.
2010. Advances in Biomedical Research : Proc.of the 7th WSEAS Internat.Conf.on Mathematical Biology and Ecology (MABE’10), the Internat.Conf.on Medical Physiology (PHYSIOLOGY’10) and the Internat.Conf.on Biochemistry and Medical Chemistry (BIOMEDCH’10), Cambridge, GB, February 23-25, 2010 WSEAS Press, 2010 (Recent Advances in Biology and Biomedicine)
Short cationic host defense peptides: determination of sequence requirements for killing pseudomonas aeruginosa
Mikut, R.; Hilpert, K.
2010. Advances in Biomedical Research : Proc.of the 7th WSEAS Internat.Conf.on Mathematical Biology and Ecology (MABE’10), the Internat.Conf.on Medical Physiology (PHYSIOLOGY’10) and the Internat.Conf.on Biochemistry and Medical Chemistry (BIOMEDCH’10), Cambridge, GB, February 23-25, 2010 WSEAS Press, 2010 (Recent Advances in Biology and Biomedicine), 327–29
2009
Sequence requirements for highly active peptides using peptide libraries
Ruden, S.; Hilpert, K.; Mikut, R.; Ulrich, A. S.
2009. CFN Summer School on Nano-Biology, Bad Herrenalb, September 8-11, 2009
Interpretable features for the activity prediction of short antimicrobial peptides using fuzzy logic
Mikut, R.; Hilpert, K.
2009. International Journal of Peptide Research and Therapeutics, 15, 129–37. doi:10.1007/s10989-009-9172-5
2008
Data-based activity analysis and interpretation of small antibacterial peptides
Mikut, R.; Reischl, M.; Ulrich, A. S.; Hilpert, K.
2008. Mikut, R. [Hrsg.] Proc.18.Workshop Computational Intelligence, Dortmund, 3.-5.Dezember 2008 Karlsruhe : Universitätsverl.Karlsruhe, 2008 (Schriftenreihe des Instituts für Angewandte Informatik/Automatisierungstechnik Universität Karlsruhe (TH) ; Bd.24)
Data-Based Activity Analysis and Interpretation of Small Antibacterial Peptides
Mikut, R.; Reischl, M.; Ulrich, A. S.; Hilpert, K.
2008. Proceedings. 18. Workshop Computational Intelligence, Dortmund, 3.-5. Dezember 2008. Hrsg.: R. Mikut, 189–203, Universitätsverlag Karlsruhe